Genotoxicity of diclofenac
WebMay 1, 2011 · In another in vitro experiment, the toxicity of diclofenac was tested in a range of concentrations of 0.001, 0.01, 0.1, 1 and 10 mg/L on three different cell types of zebra mussels: haemocytes ... WebAug 28, 2010 · A battery of eight biomarkers was used on the freshwater bivalve Dreissena polymorpha in order to evaluate potential sub-lethal effects of the nonsteroidal anti-inflammatory drug diclofenac (DCF; 2-[(2,6-dichlorophenyl)amino]phenylacetic acid). By an in vivo approach, mussels were exposed for 96 h to increasing concentrations (0.3, 1, …
Genotoxicity of diclofenac
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WebDiclofenac treatment exerted a teratogenic effect on Xenopus embryos with a teratogenic index (TI) value of 2.64 TI; if this value is higher than 1.2, the cut-off value indicative of … WebMar 15, 2024 · Due to the potential hazard of diclofenac on aquatic organisms and the lack of higher-tier ecotoxicological studies, a long-term freshwater mesocosm experiment was set up to study the effects of this substance on primary producers and consumers at environmentally realistic nominal concentrations 0.1, 1 and 10 µg/L (average effective …
WebGenotoxic impurities can get incorporated into drug substances through the various sources, the major source is the starting material used in the synthesis of drug substances and its impurities. Similarly, genotoxic intermediate and by-products formed in the synthesis process may get be carried forward to the drug substances as genotoxic ... WebAceclofenac is a monocarboxylic acid that is the carboxymethyl ester of diclofenac.A non-steroidal anti-inflammatory drug related to diclofenac, it is used in the management of osteoarthritis, rheumatoid arthritis, and ankylosing spondylitis.It has a role as an EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor, a non-steroidal anti …
WebMay 20, 2024 · Diclofenac, a nonsteroidal anti-inflammatory drug (NSAID) used to treat inflammatory diseases induces cellular toxicity by increasing the production of reactive … WebJan 1, 2016 · The estimated value for EC50 for this strain is 1.95 g/L. This is approximately five -fold higher than the value of microbial toxic concentration MTCavg (0.416 g/L). Moreover, genotoxicity...
WebDownload scientific diagram Diclofenac concentration in synovial tissue and synovial fluid 12 h after last diclofenac dose in a 7-day topical treatment regimen, analysis population. from ...
WebApr 10, 2024 · In the trapping assay with diclofenac, three adduct peaks were detected in the fluorescence chromatogram (Fig. S1A). After SIM analysis, it was revealed that Peaks 1 and 3 were acylation adducts (m/z 657), while Peak 2 was the glycation adduct (m/z 833). ... Genotoxicity of acyl glucuronide metabolites formed from clofibric acid and gemfibrozil ... blue jeans and oil art of paul jeffrey davidsWebPiperitenone oxide, a natural flavouring agent also known as rotundifolone, has been studied for the genotoxicity assessment by an integrated in vitro and in silico experimental approach, including the bacterial reverse mutation assay, the micronucleus test, the comet assay and the computational prediction by Toxtree and VEGA tools. Under our … blue jeans and moonbeams beefheartWebJan 1, 2016 · In recent years the increased consumption of diclofenac, a biologically active compound that is toxic to organisms and persistent to … blue jeans and peach topWebAug 28, 2010 · A battery of eight biomarkers was used on the freshwater bivalve Dreissena polymorpha in order to evaluate potential sub-lethal effects of the nonsteroidal anti … blue jeans and pearls galaWebFabio Barile is an academic researcher from University of Rome Tor Vergata. The author has contributed to research in topic(s): Genotoxicity. The author has an hindex of 1, co-authored 1 publication(s) receiving 13 citation(s). blue jeans and pop musicWebMar 1, 2024 · This is further substantiated by long-term bioassay data demonstrating that diclofenac sodium has no carcinogenic potential in rodents. However, more recently, … blue jeans and red shoesWebIn vitro genotoxicity of diclofenac on human lymphocytes 2010 Diclofenac is one of non-steroidal anti-inflammatory, analgesic and … blue jeans and sport coat