Cspg4-creert
WebJul 1, 2024 · CSPG4 plays a central role in the oncogenic pathways required for malignant progression and metastatization. Thanks to these features and to its poor expression in adult healthy tissues, CSPG4 represents an ideal oncoantigen and thus an attractive target for anti-tumor immunotherapy. In this review we explore the potential of CSPG4 immune ... WebJun 18, 2024 · Chondroitin sulfate proteoglycan 4 (CSPG4) is a potential receptor for C. difficile toxin B (TcdB) during C. difficile infections (CDIs). Here, the cryo-EM structure of a TcdB–CSPG4 complex and ...
Cspg4-creert
Did you know?
Chondroitin sulfate proteoglycan 4, also known as melanoma-associated chondroitin sulfate proteoglycan (MCSP) or neuron-glial antigen 2 (NG2), is a chondroitin sulfate proteoglycan that in humans is encoded by the CSPG4 gene. WebArrows indicating Cspg4/mGFP double positive cells, n = 3 biologically independent mice for each group, two-tailed unpaired t test was used (t(4) = 0.2774, p = 0.7953), scale bar = 100 μm. Points ...
WebJan 24, 2024 · Mutation details: A cre/ERT2 open reading frame and Frt-flanked neomycin cassette replaced exon 1 of the Cspg4 (NG2) locus following homologous recombination in E14.1 ES cells. The neo cassette was deleted by crossing mice to flp expressing mice. No Cspg4 protein is detected in brain lysates. () WebNational Center for Biotechnology Information
WebSep 27, 2016 · Lineage-specific tracing of remyelination by newly-formed oligodendrocytes was accomplished using the Cspg4-CreErt; Mapt-mGFP line.Recombination is induced by a single dose of tamoxifen in NG2 cells … WebDownload scientific diagram Age-related myelin renewal and memory deficits in aging mice a, Schematic diagram displaying the time course of tamoxifen induction and histology in the Cspg4-CreERt ...
WebMar 16, 2024 · The present work addressed the hypothesis that NG2/CSPG4, CD146/MCAM, and VAP1/AOC3 are target genes of myocardin-related transcription factors (MRTFs: myocardin/MYOCD, MRTF-A/MKL1, MRTF-B/MKL2 ...
Web为了模拟老化CNS髓鞘形成减少的现象,探究髓鞘形成减少与空间学习记忆能力下降的关系,研究人员构建了Cspg4-CreErt; Olig2 fl/fl;Mapt-mGFP条件敲基因小鼠。在4月龄小鼠模型中,诱导敲除OPC的转录因子Olig2。 isl hotstar highlightsWebFeb 10, 2024 · We next crossed the Cspg4-CreERt line to the mT/mG line to examine recombination efficiency in OPCs (Extended Data Fig. 4).More than 90% of Cspg4 … islhxWebCSPG4 is also known as MCSP (melanoma chondroitin sulfate proteoglycan) and NG2 (neural/glial antigen 2). The hybridoma secreting the 9.2.27 antibody was generated using a human melanoma cell extract as the immunogen. Tumor cells display a variety of antigens which have been defined by antibodies. Antibodies that specifically react with tumor ... isl hotstar liveWebPlease remember that APCU will never request your personal information, online banking credentials or one time passcode via phone, email or text. If you receive a suspicious … khabib jumping out of ringWebAug 27, 2024 · The NG2-CreERt (The Jackson Laboratory, Catalog # 008538) mouse strain has been described in a previous study (Wang et al., 2024). CreERt expression is under the transcriptional control of the … is lh still partner of cathay pacificWebTamoxifen诱导Cre-ERT2小鼠 使用指南. Cre-ERT2在无Tamoxifen诱导的情况下,在细胞质内处于无活性状态;当Tamoxifen诱导后,Tamoxifen的代谢产物4-OHT(雌激素类似 … isl hubWebIn the current studies, we identify a tumor cell surface oncoantigen, chondroitin sulfate proteoglycan 4 (CSPG4), as an independent risk factor for decreased survival of patients with EOC. Our results show that CSPG4 promotes EOC cell invasion, cisplatin resistance and spheroid formation in vitro and tumor expansion in vivo. khabib fighting bears